It’s a huge for Man City with a game against Premier League title rivals Liverpool coming up next Sunday.
First, though, they must take care of business in the Champions League as they look to maintain their 100 per cent record.
City top Group C right now having beaten all three opponents so far.
Atalanta were swept aside 5-1 last time out, while they beat Dinamo Zagreb 2-0 and eased to a 3-0 win over Shakhtar Donetsk.
Manager Pep Guardiola will be keen not to let their high standards slip, even with a tantalising clash with Liverpool on the horizon, so don’t expect too many changes.
But the Spaniard does have injury and suspension issues going into Wednesday’s match in Italy.
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Atalanta team news
Manager Gian Piero Gasperini refused to rotate his team at the weekend against Cagliari but ended up seeing his side lose 2-0 with Josip Ilicic being sent off.
There only main absence for the match with City is striker Duvan Zapata who continues to be out due to an adductor issue.
How Atalanta could line-up
Manchester City team news
Pep Guardiola has a number of injury and suspension issues on his hand entering an important week for their season.
Phil Foden might have started but will be serving a one-match suspension for his red card in the previous clash.
Elsewhere, Leroy Sane (knee), David Silva (muscle), Aymeric Laporte (knee), Rodri (hamstring), and Oleksandr Zinchenko (knee) are all absent too.
How Man City could line-up